A representative from the band claims that this slurring, near-dead rant came from Weiland being exhausted and having "a literal fistful of Quaaludes couple drinks" before the show started. We'll just leave all that up to your interpretation. The rest of us will take a passing wave at the 90s rock going by.
What you're seeing here might be a bit hard to watch. The comedian's own hiatus from comedy was in part due to creative burnout and exceedingly high audience expectations. After seeing this, it would appear his touring blitz (sometimes multiple shows in one night) are wearing him out. Whether this performance was a result of exhaustion or drunkenness is up in the air.